
Southeast Missouri Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to AU$2,500 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Southeast Missouri Holiday
Book a holiday package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri holiday today.
Southeast Missouri Holiday
Southeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Top Sights | Meramec Caverns, Mark Twain National Forest and Elephant Rocks State Park |
Our pick of the best Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$160 per night from 1 Nov to 2 Nov
AU$160
1 Nov - 2 Nov
includes taxes & fees

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
The price is AU$144 per night from 8 Nov to 9 Nov
AU$144
8 Nov - 9 Nov
includes taxes & fees

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is AU$154 per night from 15 Nov to 16 Nov
AU$154
15 Nov - 16 Nov
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southeast Missouri attractions
What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri
AU$29
per adult
96% of travellers recommend
Frequently asked questions
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.














